Anti-KI67 antibody produced in rabbit

Marker of proliferation Ki-67 (MKI67) is encoded by the gene mapped to human chromosome 10. The encoded protein is characterized by the phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal, 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.

The antiserum was produced against synthesized peptide derived from human Ki67.

Immunogen Range: 3207-3256

Anti-KI67, C-Terminal antibody produced in rabbit has been used in following studies:

• immunohistochemistry.PMID 24628875PMID 30548313PMID 30548313PMID 31860633
• immunofluorescence staining.PMID 25253741PMID 31860633
• western blottingPMID 31477564

Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, function as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered as a potential cell proliferation marker.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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