SAB4501894
Anti-MMP-7 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
MMP-7, Matrilysin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 29 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MMP7(4316)
General description
Anti-MMP-7 Antibody detects endogenous levels of total MMP-7 protein.
Matrix metalloproteinase-7 (MMP7) is also termed as matrilysin. It is located on human chromosome 11q21-->q22. It belongs to the MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human MMP-7.
Immunogen Range: 218-267
Immunogen Range: 218-267
Application
Anti-MMP-7, C-Terminal antibody has been used in immunofluorescence.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
Overexpression of matrix metalloproteinase-7 (MMP7) is observed in various cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. It is essential for the development of tumor in the absence of PKP3 (plakophilin3).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Dan-Yang Yin et al.
Clinical kidney journal, 17(1), sfad027-sfad027 (2024-01-08)
To explore the advantages of urinary matrix metalloproteinase-7 (MMP-7) in evaluating renal tubular injury in minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) patients compared with urinary cystatin C (CysC) and retinol-binding protein (RBP). Serum and urine samples were
Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases.
Zeng ZS
Clinical Cancer Research, 8(1), 144-148 (2002)
Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney
Oelusarz A, et al.
Physiological Reports, 1(5) (2013)
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Knox JD
Cytogenetics and Cell Genetics, 72(2-3), 179-182 (1996)
Anna Oelusarz et al.
Physiological reports, 1(5) (2013-11-26)
The percentage of the U.S. population over 65 is rapidly increasing, as is the incidence of chronic kidney disease (CKD). The kidney is susceptible to age-dependent alterations in structure, specifically tubulointerstitial fibrosis, that lead to CKD. Matrix metalloproteinases (MMPs) were
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