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Merck
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SAB4501939

Anti-B-MYB antibody produced in rabbit

affinity isolated antibody

Synonym(s):

BMYB, MYBB, MYBL2, Myb-related protein B

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunofluorescence
western blot
Species reactivity:
mouse, human, rat
Citations:
2
Technique(s):
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Uniprot accession no.:
P10244

Key Documents

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Product Name

Anti-B-MYB antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 79 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P10244

UniProt accession no.

P10244

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MYBL2(4605)

Related Categories

Biochem/physiol Actions

MYB proto-oncogene like 2/v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2/B-MYB) protein regulates cell proliferation, differentiation, and DNA repair. It participates in DNA replication in embryonic stem cells. MYBL2 protein can modulate stem cell genes. MYBL2 gene expression is altered in breast, ovarian, liver, colon, rectal, blood, brain, and bladder cancers. MYBL2 affects cell cycle progression and apoptosis in a regulated manner. It serves as a cell cycle modulator in hepatocellular carcinoma (HCC).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

MYB proto-oncogene like 2/v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2/B-MYB) belongs to the MYB family of transcription factors. MYBL2 gene is located on human chromosome 20q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human B-Myb.

Immunogen Range: 551-600

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
210823

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Z Guan et al.
Current research in translational medicine, 66(1), 27-32 (2017-12-25)
In this study, we aimed to assess the association between MYBL2 expression/transcription regulatory activity (TRA) and overall survival (OS) in patients with primary hepatocellular carcinoma (HCC) and to explore the factors related to B-Myb TRA. Bioinformatic analysis was performed based
Rachel Bayley et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188407-188407 (2020-08-28)
The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes including cell proliferation, differentiation and DNA repair. Changes in these pathways can facilitate cancer development and as such targeting these processes represent an effective method to

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