SAB4502822
Anti-SMO antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Gx protein, SMO
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-SMO antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 86 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SMO(6608)
Related Categories
Biochem/physiol Actions
The SMO (smoothened) gene encodes a protein that mediates hedgehog signaling for embryonic development and to maintain tissue homeostasis. SMO participates in tumor cell proliferation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-SMO antibody detects endogenous levels of total SMO protein.
The SMO (smoothened) gene is mapped to human chromosome 7q32.1. It encodes a protein that belongs to the frizzled family of G protein-coupled receptors. It is a seven transmembrane protein and highly conserved.
Immunogen
The antiserum was produced against synthesized peptide derived from human SMO.
Immunogen Range: 68-117
Immunogen Range: 68-117
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis.
Zhu SL
Cellular & Molecular Immunology, 14(2), 214-222 (2017)
Identification of Novel Smoothened Ligands Using Structure-Based Docking.
Lacroix C
PLoS ONE, 11(8), 1-20 (2016)
Epigenetics Offer New Horizons for Colorectal Cancer Prevention.
Schnekenburger M and Diederich M
Current Colorectal Cancer Reports, 8(1), 66-81 (2012)
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