SAB5500118
Anti-HLA-DP alpha 1 antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP228, affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP228, monoclonal
species reactivity
human (tested)
technique(s)
flow cytometry: 1:100
immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... HLA-DPA1(3113)
Related Categories
General description
HLA-DP is an antigen receptor and one of the MHC class II proteins. HLA-DP is a heterodimer of an alpha and a beta chain. Both chains are type I transmembrane proteins with short cytoplasmic domains. It is expressed on antigen-presenting cells and a variety of other cell types, and is also expressed by various tumors such as melanoma, gastric carcinoma, breast carcinoma, ovarian carcinoma, and lymphoma.
Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) is a class II heterodimer comprising of a polymorphic β and an oligomorphic α chain. It is encoded by the gene mapped to human chromosome 6p21.33. HLA-DPA1 is generally expressed on a subset of Kupffer cells and resident macrophages in liver.
Immunogen
Synthetic peptide derived from human HLA-DP alpha1 protein.
Application
Anti-HLA-DP alpha 1 antibody, Rabbit monoclonal has been used in immunohistochemistry.
Biochem/physiol Actions
Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) alloreactivity is highly relevant in clinical transplantation. It plays an essential role in the presentation of viral antigens to CD4+ T helper (Th) lymphocytes. Studies have suggested that SNP (single nucleotide polymorphisms) of HLA-DP can result in chronic hepatitis B virus (HBV) infection.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus Infections, Possibly through Interacting with Viral Mutations
Zhang Q, et al.
Journal of Virology, 02073-02073 (2013)
Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGF?1/ERK/NF-?B axis.
Wang Y, et al.
Biochimica et Biophysica Acta, 1860(7), 1551-1559 (2016)
New loci associated with chronic hepatitis B virus infection in Han Chinese.
Hu Z, et al.
Nature Genetics, 45(12), 1499-1499 (2013)
Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.
Lauterbach N, et al.
Molecular Immunology, 59(1), 19-29 (2014)
Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection
Su M, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 31(6), 765-769 (2014)
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