SAB5702198
Anti-C-RAF antibody
rabbit monoclonal, 4G6C1
Synonym(s):
CMD1NN,CRAF,NS5,Raf-1,c-Raf,RAF1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.46
Clone:
4G6C1, monoclonal
Technique(s):
western blot: 1:500 - 1:2000
Application:
WB
Citations:
-
Product Name
Anti-Raf1 Antibody, clone 4G6C1, Rabbit Monoclonal,
biological source
rabbit
material
colorless
clone
4G6C1, monoclonal
form
liquid
mol wt
74 kDa
concentration
2 mg/mL
technique(s)
western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFR
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RAF1(5894)
species reactivity
human
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General description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Raf1 (P04049).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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