SML0007
Cevimeline hydrochloride hemihydrate
≥95% (HPLC, NMR)
Synonym(s):
AF-102B, SNI-2011
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About This Item
Empirical Formula (Hill Notation):
C10H17NOS · xHCl · yH2O
CAS Number:
Molecular Weight:
199.31 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC, NMR)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC, NMR)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥25 mg/mL
originator
Daiichi-Sankyo
shipped in
wet ice
storage temp.
−20°C
SMILES string
O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6
InChI
1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1
InChI key
ZSTLCHCDLIUXJE-GMLJRNIPSA-N
Application
Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.
Biochem/physiol Actions
Cevimeline stimulates the peripheral muscarinic acetylcholine receptors of salivary glands and increases the concentration of Ca+2 in parotic acini and duct cells of rats. It thus acts as therapeutic agent for xerostomia.
Cevimeline is a muscarinic M1 and M3 receptor agonist.
Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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