Skip to Content
Merck
CN

SML0007

Cevimeline hydrochloride hemihydrate

≥95% (HPLC, NMR)

Synonym(s):

AF-102B, SNI-2011

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C10H17NOS · xHCl · yH2O
CAS Number:
153504-70-2
Molecular Weight:
199.31 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825084
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6

InChI

1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1

InChI key

ZSTLCHCDLIUXJE-GMLJRNIPSA-N

assay

≥95% (HPLC, NMR)

form

powder

storage condition

desiccated

color

white to tan

solubility

H2O: ≥25 mg/mL

originator

Daiichi-Sankyo

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

Application

Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.

Biochem/physiol Actions

Cevimeline is a muscarinic M1 and M3 receptor agonist.
Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.
Cevimeline stimulates the peripheral muscarinic acetylcholine receptors of salivary glands and increases the concentration of Ca+2 in parotic acini and duct cells of rats. It thus acts as therapeutic agent for xerostomia.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000466805
0000466805
051M4709V
0000128343
0000128342

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hirotaka Ueda et al.
The journal of medical investigation : JMI, 56 Suppl, 267-269 (2009-01-01)
Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is distributed in the brain after its oral administration, it is possible that it
Kentaro Ono et al.
The journal of medical investigation : JMI, 56 Suppl, 375-375 (2009-01-01)
Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that

Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service