SML0016
CCG-63802
Synonym(s):
α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
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About This Item
Empirical Formula (Hill Notation):
C26H18N4O2S
CAS Number:
Molecular Weight:
450.51
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
Quality Level
form
powder
color
yellow
solubility
DMSO: ≥5 mg/mL (;warmed DMSO)
storage temp.
room temp
Application
CCG-63802 may be used to study G-protein-mediated cell signaling.
Biochem/physiol Actions
CCG-63802 is a reversible, allosteric inhibitor of RGS4
GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Heterotrimeric G proteins modulate intracellular signals from 7TM receptors, impacting various cellular functions and drug targets.
We offers many products related to opioid receptors for your research needs.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0016-5MG | 04061832559636 |
| SML0016-25MG | 04061832559629 |