SML0016
CCG-63802
Synonym(s):
α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
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About This Item
Empirical Formula (Hill Notation):
C26H18N4O2S
CAS Number:
Molecular Weight:
450.51
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
Quality Segment
form
powder
color
yellow
solubility
DMSO: ≥5 mg/mL (;warmed DMSO)
storage temp.
room temp
Application
CCG-63802 may be used to study G-protein-mediated cell signaling.
Biochem/physiol Actions
CCG-63802 is a reversible, allosteric inhibitor of RGS4
GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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