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Merck
CN

SML0198

Fenoldopam mesylate

≥98% (HPLC)

Synonym(s):

Fenoldopam methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO3 · CH4O3S
CAS Number:
67227-57-0
Molecular Weight:
401.86
NACRES:
NA.77
PubChem Substance ID:
329825223
UNSPSC Code:
12352200
EC Number:
266-612-7
MDL number:
MFCD04112986
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

Fenoldopam mesylate, ≥98% (HPLC)

InChI key

CVKUMNRCIJMVAR-UHFFFAOYSA-N

InChI

1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)

SMILES string

CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

mp

271 °C (lit.)

solubility

DMSO: ≥15 mg/mL at ~60 °C

storage temp.

room temp

Quality Level

100

Gene Information

human ... DRD1(1812)

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Related Categories

Application

Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.

Biochem/physiol Actions

Dopamine D1-receptor agonist; Antihypertensive
Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000192954
0000192953
0000192954
0000192953
0000130812

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Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients
Hammer GB, et al.
BMC anesthesiology, 8(1), 6-6 (2008)
The pharmacokinetics of intravenous fenoldopam in healthy, awake cats
O'Neill KE, et al.
Journal of Veterinary Pharmacology and Therapeutics, 39, 202-204 (2016)
51 What is the value of Non-Dialytic therapy in acute kidney injury
Evidence-Based Practice of Critical Care E-book: Expert Consult, 359-359 (2010)
A D Knapton et al.
Methods and findings in experimental and clinical pharmacology, 32(7), 489-497 (2010-11-12)
Exposure of the vasculature to vasodilators, pharmaceuticals and industrial chemicals may lead to injury of the blood vessel wall in animals. Vascular injury may begin with changes in the permeability of vascular endothelial cell and vessels, resulting in possible hemorrhage
Shetal H Padia et al.
Hypertension (Dallas, Tex. : 1979), 59(2), 437-445 (2011-12-29)
Renal dopamine D(1)-like receptors (D(1)Rs) and angiotensin type 2 receptors (AT(2)Rs) are important natriuretic receptors counterbalancing angiotensin type 1 receptor-mediated tubular sodium reabsorption. Here we explore the mechanisms of D(1)R and AT(2)R interactions in natriuresis. In uninephrectomized, sodium-loaded Sprague-Dawley rats
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