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SML0229

CIQ

Name: CIQ
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

(3-Chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₆ClNO₅

CAS Number:

486427-17-2

Molecular Weight:

467.94

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

storage temp.

2-8°C

SMILES string

Clc1cc(ccc1)C(=O)N2CCc3c(cc(c(c3)OC)OC)C2COc4ccc(cc4)OC

InChI

1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3

InChI key

VYMILMYEENZHAR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CIQ is a selective NR2C/NR2D-containing NMDA potentiator

CIQ is positive allosteric modulator of NR2C/NR2D subunit containing NMDA receptors. CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC₅₀ = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. The compound does not alter the EC₅₀ values for glutamate or glycine on channel opening.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Glutamate Receptors (Ion Channel Family)

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Global Trade Item Number

SKU	GTIN
SML0229-5MG	04061832075228
SML0229-25MG	04061832075211

Key Documents

CIQ

≥98% (HPLC)

Select a Size

About This Item

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Biochem/physiol Actions

Features and Benefits

Still not finding the right product?

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

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Protocols and Articles

Articles

Global Trade Item Number