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Merck
CN

SML0453

TBPB

≥98% (HPLC)

Synonym(s):

1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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About This Item

Empirical Formula (Hill Notation):
C25H32N4O
CAS Number:
634616-95-8
Molecular Weight:
404.55
NACRES:
NA.77
PubChem Substance ID:
329824732
UNSPSC Code:
12352200
MDL number:
MFCD22666590

Key Documents

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Product Name

TBPB, ≥98% (HPLC)

InChI

1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)

SMILES string

Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45

InChI key

CWPKTBMRVATCBL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution; warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist.
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
082M4626V

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Ashwini Kumar et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 115(1), 3-10 (2015-07-30)
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Ionic clathrate hydrates can selectively capture small gas molecules such as CO
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Journal of environmental management, 268, 110340-110340 (2020-05-10)
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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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