SML0453
TBPB
≥98% (HPLC)
Synonym(s):
1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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About This Item
Empirical Formula (Hill Notation):
C25H32N4O
CAS Number:
Molecular Weight:
404.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution; warmed)
storage temp.
2-8°C
SMILES string
Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45
InChI
1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
InChI key
CWPKTBMRVATCBL-UHFFFAOYSA-N
Biochem/physiol Actions
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist.
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
Ashwini Kumar et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 115(1), 3-10 (2015-07-30)
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline, i.e., dementia. The disease starts with mild symptoms and gradually becomes severe. AD is one of the leading causes of
Hidenori Hashimoto et al.
Scientific reports, 7(1), 17216-17216 (2017-12-10)
Ionic clathrate hydrates can selectively capture small gas molecules such as CO
Aleksei Furletov et al.
Sensors (Basel, Switzerland), 20(17) (2020-09-02)
Nowadays, analytical systems based on silver triangular nanoplates (AgTNPs) have been shown as good prospects for chemical sensing. However, they still remain relatively poorly studied as colorimetric probes for sensing various classes of compounds. This study shows that these nanoparticles
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0453-5MG | 04061832075785 |
| SML0453-25MG | 04061832075778 |