SML0462
Alda-1
≥98% (HPLC)
Synonym(s):
N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
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About This Item
Empirical Formula (Hill Notation):
C15H11Cl2NO3
CAS Number:
Molecular Weight:
324.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
Alda-1, ≥98% (HPLC)
InChI
1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
SMILES string
Clc1cccc(Cl)c1C(=O)NCc2ccc3OCOc3c2
InChI key
NMKJFZCBCIUYHI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
Related Categories
Application
Alda-1 has been used as an aldehyde dehydrogenase 2 (ALDH2) agonist:
- to study its cryoprotective effects on H2O2-induced Achilles tendinopathy in mice Achilles tenocytes
- to study its protective effects against alcohol-derived DNA damage in ALDH2 knock out mice
- to study its effects on cutaneous wound healing in mice
Biochem/physiol Actions
Alda-1 is an ALDH2 agonist; cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2.
Alda-1 is an ALDH2 agonist; cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2. ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. It appears that Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding, but does not improve the nitroglycerin binding affinity of the Asian variant.
Alda-1 plays a role in reducing the damage caused by oxidative stress in several human cells like lung endothelial, umbilical vein endothelial, and hepatic cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Tingting Fang et al.
Molecular medicine reports, 18(3), 2807-2815 (2018-07-18)
The aim of the present study was to investigate whether necroptosis occurs in high glucose (HG)-induced H9c2 cardiac cell injury and whether the activation of aldehyde dehydrogenase 2 (ALDH2) can inhibit necroptosis. H9c2 cardiac cells were treated with 35 mM glucose
Gina D Kusuma et al.
Scientific reports, 7, 42397-42397 (2017-02-17)
High resistance to oxidative stress is a common feature of mesenchymal stem/stromal cells (MSC) and is associated with higher cell survival and ability to respond to oxidative damage. Aldehyde dehydrogenase (ALDH) activity is a candidate "universal" marker for stem cells.
Sahebgowda Sidramagowda Patil et al.
Frontiers in pharmacology, 11, 597942-597942 (2021-02-19)
Acute lung injury (ALI), a milder form of acute respiratory distress syndrome (ARDS), is a leading cause of mortality in older adults with an increasing prevalence. Oxygen therapy, is a common treatment for ALI, involving exposure to a high concentration
Che-Hong Chen et al.
EBioMedicine, 55, 102753-102753 (2020-05-14)
Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, including acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes.
Qiankun Zhu et al.
Clinical science (London, England : 1979), 131(11), 1123-1136 (2017-03-23)
Many studies demonstrate that activation of aldehyde dehydrogenase 2 (ALDH2) protects against oxidative stress via detoxification of cytotoxic aldehydes, and could attenuate cardiac, cerebral, lung and renal ischaemia-reperfusion (I/R) injuries. However, the effect of ALDH2 in intestinal I/R is unknown. The
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