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SML0473

Noladin ether

Name: Noladin ether
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

2-Arachidonylglyceryl ether, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yloxy]-1,3-propanediol; 2-AG ether, HU 310

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₄₀O₃

CAS Number:

222723-55-9

Molecular Weight:

364.56

UNSPSC Code:

12352200

EC Number:

200-578-6

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solution

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solution

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

concentration

10 mg/mL in ethanol (1% w/v)

color

colorless to light yellow

shipped in

dry ice

storage temp.

−70°C

SMILES string

O(C(CO)CO)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC

InChI

1S/C23H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26-23(21-24)22-25/h6-7,9-10,12-13,15-16,23-25H,2-5,8,11,14,17-22H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChI key

CUJUUWXZAQHCNC-DOFZRALJSA-N

Description

Biochem/physiol Actions

Noladin ether (2-Arachidonyl glycerol ether) is a CB1 agonist.

Noladin ether (2-Arachidonyl glycerol ether) is a stable analog of the endogenous cannabanoid 2-Arachidonylglycerol (2-AG) with selectivity for CB1 receptors. Noladin ether is a CB1 agonist. The Ki values for CB1 vs CB2 receptors are 21.2 nM and 3 mM, respectively. Noladin ether induces sedation and has modest antinociceptive activity in vivo, and reduces inter ocular pressure after administration in the eye.