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SML0510

S 26948

Name: S 26948
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester, S26948

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₅NO₇S

CAS Number:

353280-43-0

Molecular Weight:

519.57

NACRES:

NA.77

PubChem Substance ID:

329825519

UNSPSC Code:

12352200

MDL number:

MFCD18086885

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

COC(=O)C(Cc1ccc(OCCN2C(=O)Sc3cc(ccc23)C(=O)c4ccccc4)cc1)C(=O)OC

InChI

1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3

InChI key

NSMJEHGOMXSLCW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

S 26948 belongs to the non-thiazolidinedione (TZD) class of drugs. It has the potential to treat diabetes and atherogenesis.

S 26948 is a partial PPARγ agonist; selective PPARγ modulator (SPPARγM).

S 26948 is a selective PPARγ modulator (SPPARγM). S 26948 is as effective as rosiglitazone in reducing insulin resistance and lipid homeostasis, but does not increase body or white adipose tissue weight. S 26948 also leads to different co-activatior recruitment to PPARγ than rosiglitazone.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Nuclear Receptors (Non-Steroids)

We offer many products related to non-steroid nuclear receptors for your research needs.

Global Trade Item Number

SKU	GTIN
SML0510-25MG	04061832954820
SML0510-5MG	04061832954837

Key Documents

S 26948

≥98% (HPLC)

Select a Size

About This Item

Quality Segment

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Biochem/physiol Actions

Features and Benefits

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Regulatory Information

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Protocols and Articles

Articles

Product Citations

Global Trade Item Number