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Merck
CN

SML0571

SB-612111 hydrochloride

≥98% (HPLC), Nociceptin receptor antagonist, powder

Synonym(s):

(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C24H29Cl2NO · HCl
CAS Number:
371980-98-2
Molecular Weight:
454.86
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

SB-612111 hydrochloride, ≥98% (HPLC)

SMILES string

Clc1c(c(ccc1)Cl)C2CCN(CC2)C[C@@H]3C[C@@H](c4c(c(ccc4)C)CC3)O.Cl

InChI

1S/C24H29Cl2NO.ClH/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26;/h2-7,17-18,23,28H,8-15H2,1H3;1H/t17-,23-;/m0./s1

InChI key

DCKUVQADDNMWEF-DQFHVVJASA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

SB-612111 is a potent antagonist of the nociceptin receptor ORL-1. SB-612111 binds to ORL-1 with high affinity (Ki = 0.33 nM) but has very low affinity for classic opioid receptors. The compound SB-612111 antagonizes the anti-morphine effects of nociceptin and blocks nociceptin-induced thermal hyperalgesia.
SB-612111 is an opiate receptor-like orphan receptor (ORL-1).

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000516645
0000516645
0000424382
0000424382
0000156150

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Articles

Opioid Receptors

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