SML0976
Siramesine fumarate salt
≥98% (HPLC)
Synonym(s):
1′-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4′-piperidine] fumarate salt, Lu 28-179
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About This Item
Empirical Formula (Hill Notation):
C30H31FN2O · C4H4O4
CAS Number:
Molecular Weight:
570.65
NACRES:
NA.77
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Siramesine or Lu 28-179 (1′-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4′-piperidine]) is considered as a drug for depression and anxiety. This lysosomotropic agent stimulates mitochondrial membrane potential (MMP) reduction and the production of ROS (reactive oxygen species).
Siramesine is a blood-brain barrier penetrant, selective and potent sigma-2 receptor agonist, which exhibits potent and very long-lasting anxiolytic effects in rodents. Also, siramesine is a lysosome-destabilizing agent that causes lysosomal cell death in varies immortalized and cancer cell lines.
Siramesine is a blood-brain barrier penetrant, selective and potent sigma-2 receptor agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
DISCOVER Bioactive Small Molecules for Neuroscience
Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies.
Henriet, et al.
Brain, 146, 2453-2463 (2023)
Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes.
Cesen MH, et al.
Cell Death & Disease, 4(10), e818-e818 (2013)
Z H Zhang et al.
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 42(5), 407-414 (2021-07-05)
Objective: To clarify the effects of bortezomib combined with or without siramesine on the proliferation of multiple myeloma cell lines, the expression changes of transcription factor EBC (TFEB) nuclear translocation and the level of autophagy, and to provide basis for
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0976-25MG | 04061832560489 |
| SML0976-5MG | 04061832560496 |