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Merck
CN

SML1070

SR-58611A

≥98% (HPLC)

Synonym(s):

Amibegron, [[(7S)-7-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy acetic acid ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H26ClNO4 · HCl
CAS Number:
121524-09-2
Molecular Weight:
440.36
NACRES:
NA.77
PubChem Substance ID:
329825649
UNSPSC Code:
12352200
MDL number:
MFCD00886563

Key Documents

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Product Name

SR-58611A, ≥98% (HPLC)

InChI

1S/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1

SMILES string

ClC1=CC([C@@H](O)CN[C@@H]2CC(C=C(OCC(OCC)=O)C=C3)=C3CC2)=CC=C1.Cl

InChI key

NQIZCDQCNYCVAS-RQBPZYBGSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -75 to -95°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Gene Information

human ... ADRB3(155)

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Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Biochem/physiol Actions

SR58611A is a potent, specific 3β adrenergic receptor agonist.
SR58611A is a potent, specific b3 adrenergic receptor agonist. The EC50 for reduction of β3-mediated spontaneous motility in rat distal colon sections is 3.5 nM. Minimal anti-depressant efficacious doses for SR58611A are 0.1-0.3 mpk in rodent models.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000483778
0000483778
0000481130
0000481130
0000096672

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Zili Wang et al.
Journal of shoulder and elbow surgery, 30(2), 373-386 (2020-07-01)
Rotator cuff (RC) muscle atrophy and fatty infiltration (FI) are independent factors correlated with failure of attempted tendon repair in larger RC tears. However, there is no effective treatment for RC muscle atrophy and FI at this time. The recent

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