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Merck
CN

SML1159

XIB4035

≥98% (HPLC)

Synonym(s):

N4-[7-Chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-1,4-pentanediamine

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About This Item

Empirical Formula (Hill Notation):
C26H31Cl2N3
CAS Number:
529507-84-4
Molecular Weight:
456.45
NACRES:
NA.77
PubChem Substance ID:
329825689
UNSPSC Code:
51111800
MDL number:
MFCD00601670

Key Documents

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Product Name

XIB4035, ≥98% (HPLC)

InChI

1S/C26H31Cl2N3/c1-4-31(5-2)16-8-9-19(3)29-26-18-22(14-12-20-10-6-7-11-24(20)28)30-25-17-21(27)13-15-23(25)26/h6-7,10-15,17-19H,4-5,8-9,16H2,1-3H3,(H,29,30)/b14-12+

SMILES string

ClC1=CC=CC=C1/C=C/C2=NC3=C(C=CC(Cl)=C3)C(NC(C)CCCN(CC)CC)=C2

InChI key

CMLVHSVFSYNMGM-WYMLVPIESA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

XIB4035 is a reported agonist of the glial cell-line derived neurotrophic factor (GDNF) receptor GFRα1.
XIB4035 is a reported agonist of the glial cell-line derived neurotrophic factor (GDNF) receptor GFRα1. XIB4035 induces GFRα1/RET phosphorylation in Neuro2A cells.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000500081
0000500081
0000143932
0000127167
0000127168

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Sean Jmaeff et al.
Molecular pharmacology, 98(1), 1-12 (2020-05-05)
Glial cell line-derived neurotrophic factor (GDNF) binds the GFRα1 receptor, and the GDNF-GFRα1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways. To dissect the GDNF-GFRα1-RET signaling complex, agents that bind and activate

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