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SML1236

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC), acetylcholine receptor agonist, powder

Synonym(s):

(−)-Nicotine ditartrate, (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt

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About This Item

Empirical Formula (Hill Notation):
C10H14N2 · 2C4H6O6
CAS Number:
65-31-6
Molecular Weight:
462.41
UNSPSC Code:
12352210
PubChem Substance ID:
329825736
NACRES:
NA.77
EC Number:
200-607-2
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Product Name

(−)-Nicotine hydrogen tartrate salt, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +20 to +26°, c = 1.0 in water

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

SMILES string

CN1CCC[C@H]1C2=CC=CN=C2.C

InChI

1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1

InChI key

RYYKFQGHMYGLEL-PPHPATTJSA-N

Application

(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.
(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).

Biochem/physiol Actions

NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer’s disease, Parkinson’s disease and ulcerative colitis.
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

289.8 °F

flash_point_c

143.2 °C

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
045M4757V
0000378455
045M4757V
0000378455
0000514199

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Mahmoud M Farag et al.
European journal of pharmacology, 720(1-3), 1-6 (2013-11-12)
The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine
Metabolism and disposition kinetics of nicotine.
Hukkanen J, et al.
Pharmacological Reviews, 57(1), 79-115 (2005)
Nicotine hydrogen tartrate loaded chitosan nanoparticles: Formulation, characterization and in vitro delivery from dry powder inhaler formulation.
Wang H, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 113, 118-131 (2017)
View All Related Papers

Global Trade Item Number

SKUGTIN
SML1236-1G04061825983561
SML1236-50MG04061837107757