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SML1314

SAG dihydrochloride

Name: SAG dihydrochloride
Brand: SIGMA

≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist

Synonym(s):

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide dihydrochloride, Smoothened Agonist

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₈ClN₃OS · 2HCl

CAS Number:

912545-86-9

Molecular Weight:

562.98

UNSPSC Code:

51111800

PubChem Substance ID:

329825779

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

lyophilized solid

Quality level:

100

Storage condition:

desiccated

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Product Name

SAG dihydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

lyophilized solid

storage condition

desiccated

color

white to beige

solubility

H₂O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4

InChI

1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-

InChI key

VFSUUTYAEQOIMW-YHBQERECSA-N

Related Categories

Bioactive Small Molecules

Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:

to study its effects on mouse hippocampal cells
to determine its effects on the mitochondrial network in zebrafish embryo
to study its effects on murine embryonic fibroblasts

Biochem/physiol Actions

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

SAG is a potent and cell-permeable smoothened (Smo) agonist.

pictograms

GHS06

signalword

Danger

hcodes

H301,H413

pcodes

P264 - P270 - P273 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Differential role of Pax6 and its interaction with Shh-Gli1-IDH2 axis in regulation of glioma growth and chemoresistance.

Shirin Farheen et al.

Journal of biochemical and molecular toxicology, 37(2), e23241-e23241 (2022-10-08)

Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary therapies provide a chance of survival for 9-12 months. Therefore, a novel approach is essential to improve the survival rate. Sonic hedgehog (Shh) cell signaling

Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer.

Lina Zhu et al.

PeerJ, 10, e13381-e13381 (2022-05-10)

Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane

GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.

Maike Marczenke et al.

Development (Cambridge, England), 148(21) (2021-10-27)

Growth arrest-specific 1 (GAS1) acts as a co-receptor to patched 1, promoting sonic hedgehog (SHH) signaling in the developing nervous system. GAS1 mutations in humans and animal models result in forebrain and craniofacial malformations, defects ascribed to a function for

FGF signaling refines Wnt gradients to regulate the patterning of taste papillae.

Michaela Prochazkova et al.

Development (Cambridge, England), 144(12), 2212-2221 (2017-05-17)

The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue.

Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions.

Alp Ozgun et al.

Materials today. Bio, 25, 100992-100992 (2024-02-19)

Modern in vitro technologies for preclinical research, including organ-on-a-chip, organoids- and assembloid-based systems, have rapidly emerged as pivotal tools for elucidating disease mechanisms and assessing the efficacy of putative therapeutics. In this context, advanced in vitro models of Parkinson's Disease

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Global Trade Item Number

SKU	GTIN
SML1314-5MG	04061833225660
SML1314-1MG	04061837107832

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