SML1455
DAA-I acetate salt
≥98% (HPLC)
Synonym(s):
5-L-Isoleucine-2-10-Angiotensin I acetate salt, Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu acetate, RVYIHPFHL acetate, [Des-Asp1-Ile5]angiotensin I, des-Asp-angiotensin I acetate, des-aspartate-angiotensin-I acetate
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About This Item
Empirical Formula (Hill Notation):
C58H84N16O11 · xC2H4O2
CAS Number:
Molecular Weight:
1181.39 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Product Name
DAA-I acetate salt, ≥98% (HPLC)
assay
≥98% (HPLC)
form
film
color
colorless
shipped in
wet ice
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor and releases prostaglandins which mediate its actions. DAA-I administer at doses lesser than Km of metabolizing enzymes antagonize the deleterious actions of angiotensin II. DAA-I appear function in vivo as a physiological antagonist to angiotensin II.
DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor.
Des-aspartate-angiotensin I (DAA-I) is a nine-amino acid angiotensin peptide and a metabolite of angiotensin DAA-I mediates attenuation of early inflammatory processes and intercellular adhesion molecule-1 (ICAM-1) formation in animal models.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Meng-Kwoon Sim et al.
Regulatory peptides, 188, 40-45 (2013-12-18)
L6 skeletal muscle cells overexpressed ICAM-1 when treated with H2O2. Maximum effect was observed at 200 μM H2O2. Des-aspartate-angiotensin I (DAA-I) concentration-dependently attenuated the overexpression. Maximum attenuation occurred at 10(-10) M DAA-I. H2O2 activated NFκB and its translocation into the
Lay-Teng Ang et al.
European journal of pharmacology, 683(1-3), 310-315 (2012-03-06)
The high frequency of rhinovirus (RV) infection and the lack of an effective treatment, underline the importance of research on novel anti-rhinoviral agents. The present study investigated the effects of des-aspartate-angiotensin I (DAA-I) on the survival of RV14-infected H1HeLa cells;
M R Mustafa et al.
Regulatory peptides, 120(1-3), 15-22 (2004-06-05)
An earlier study showed that des-aspartate-angiotensin I (DAA-I) attenuated the pressor action of angiotensin III in aortic rings of the spontaneously hypertensive rat (SHR) but not the normotensive Wistar Kyoto (WKY) rat. The present study investigated similar properties of DAA-I
Ko-Onn Lee et al.
Drugs in R&D, 16(4), 317-326 (2016-09-30)
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT
Hong Wang et al.
PloS one, 10(9), e0138009-e0138009 (2015-09-18)
ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathways that are up-regulated during
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