SML1464
SMBA1
≥98% (HPLC)
Synonym(s):
2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol, 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
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About This Item
Empirical Formula (Hill Notation):
C20H13NO3
CAS Number:
Molecular Weight:
315.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
OC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C\2C=C([N+]([O-])=O)C=C4
InChI
1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
InChI key
PEYKRJBXACUOOB-WOJGMQOQSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
SMBA1 is a potent and selective Bax agonist.
SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.
Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Shuangbo Fan et al.
Pharmacology, 105(3-4), 164-172 (2019-12-23)
SMBA1 (small-molecule Bax agonists 1), a small molecular activator of Bax, is a potential anti-tumour agent. In the present study, we investigated the biological effects of SMBA1 on glioblastoma (GBM) cells. SMBA1 reduced the viabilities of U87MG, U251 and T98G
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