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Merck
CN

SML1504

Tegaserod maleate

≥98% (HPLC)

Synonym(s):

2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate

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About This Item

Empirical Formula (Hill Notation):
C16H23N5O · C4H4O4
CAS Number:
189188-57-6
Molecular Weight:
417.46
NACRES:
NA.77
PubChem Substance ID:
329825925
UNSPSC Code:
12352200
MDL number:
MFCD09028009

Key Documents

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Product Name

Tegaserod maleate, ≥98% (HPLC)

InChI key

CPDDZSSEAVLMRY-FEQFWAPWSA-N

SMILES string

N=C(NCCCCC)N/N=C/C1=CNC2=C1C=C(OC)C=C2.OC(/C=C\C(O)=O)=O

InChI

1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... HTR4(3360)

Related Categories

Application

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

Biochem/physiol Actions

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
Tegaserod is a potent full agonist at serotonin 5-HT4 receptors with an EC50 of 7 nM.
Tegaserod is a serotonin 5-HT4 agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000362269
0000362269
0000219164
0000219164
0000184196

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Screening of clinically-applicable drugs in patient-derived glioblastoma stem-like cells identifies amiodarone, clofazimine and triptolide as potential anti-glioma agents
Sigrid S
Combinatorial Chemistry: From Theory to Application (2015)
Corrado Blandizzi and Carmelo Scarpignato
Side Effects of Drugs Annual: A world-wide yearly survey of new data and trends in adverse drug reactions., 33, 741-767 (2011)

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