SML1879
A-395N
≥98% (HPLC)
Synonym(s):
(3S,4R)-1-Benzyl-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine, (3S,4R)-{1-Benzyl-4-[4-(4-methanesulfonyl-piperazin-1-yl)-phenyl]-pyrrolidin-3-yl}-dimethyl-amine
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About This Item
Empirical Formula (Hill Notation):
C24H34N4O2S
CAS Number:
Molecular Weight:
442.62
NACRES:
NA.77
UNSPSC Code:
12352204
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +1.0 to +3.0°, c = 1 in chloroform-d
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
A-395N is a control probe for A-395, which is a chemical probe for polycomb protein EED. A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395N is structurally similar, but exhibits no activity in the biochemical and cellular assays, so is an ideal control compound. For characterization details of the active probe, A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.
A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-395N is a control probe for A-395, which is a chemical probe for polycomb protein EED..
Features and Benefits
A-395N is a negative control for A-395, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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