Name: RO5256390
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₈N₂O

CAS Number:

1043495-96-0

Molecular Weight:

218.29

MDL number:

MFCD28405494

UNSPSC Code:

12352200

NACRES:

NA.77

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Product Name

RO5256390, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 14 to 19°, c = 1 in methanol

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC[C@@H](C[C@H]1COC(N)=N1)C2=CC=CC=C2

InChI

1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1

InChI key

IXDKFUBXESWHSL-JQWIXIFHSA-N

Biochem/physiol Actions

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaine′s reinforcng effects, and blocks binge-eating disorder.

TAAR1 agonist

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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