SML1893
RO5256390
≥98% (HPLC), TAAR1 agonist, powder
Synonym(s):
(S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine
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About This Item
Empirical Formula (Hill Notation):
C13H18N2O
CAS Number:
Molecular Weight:
218.29
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
RO5256390, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D 14 to 19°, c = 1 in methanol
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC[C@@H](C[C@H]1COC(N)=N1)C2=CC=CC=C2
InChI
1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1
InChI key
IXDKFUBXESWHSL-JQWIXIFHSA-N
Biochem/physiol Actions
RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaine′s reinforcng effects, and blocks binge-eating disorder.
TAAR1 agonist
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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