Skip to Content
Merck
CN

SML2049

Sigma-Aldrich

AR-R17779 Hydrochloride

≥97% (HPLC)

Synonym(s):

(-)-AR-R 13489 HCl, (-)-AR-R13489 HCl, (-)-Spiro[1-azabicyclo[2.2. 2]octane-3,5′-oxazolidin]-2′-one hydrochloride; (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidine]-2′-one hydrochloride, (S)-AR-R 13489 HCl, (S)-AR-R13489 HCl, AR-R 17779 HCl

Sign Into View Organizational & Contract Pricing

Select a Size

1 KIT
CN¥5,282.92

CN¥5,282.92


In StockDetails

New, lower price on this item!

Request a Bulk Order

Select a Size

Change View
1 KIT
CN¥5,282.92

About This Item

Empirical Formula (Hill Notation):
C9H14N2O2 · HCl
CAS Number:
Molecular Weight:
218.68
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥5,282.92


In StockDetails

New, lower price on this item!

Request a Bulk Order

Assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -59 to -69°, c = 1.0 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1O[C@@]2(CN1)CN3CCC2CC3.Cl

InChI

1S/C9H14N2O2.ClH/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11;/h7H,1-6H2,(H,10,12);1H/t9-;/m0./s1

InChI key

XGLBLUBBDSJBIU-FVGYRXGTSA-N

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
487554P13800189235
assay

97%

assay

99% (CP)

assay

98%

assay

98%

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

density

0.973 g/mL at 25 °C (lit.)

density

1.053 g/mL at 25 °C

density

1.012 g/mL at 25 °C (lit.)

density

0.973 g/mL at 25 °C (lit.)

form

powder

form

-

form

-

form

liquid

mp

28-32 °C (lit.)

mp

19-20 °C (lit.)

mp

19-20 °C (lit.)

mp

-

refractive index

n20/D 1.5196 (lit.)

refractive index

n20/D 1.532 (lit.)

refractive index

n20/D 1.527 (lit.)

refractive index

n20/D 1.522 (lit.)

Biochem/physiol Actions

AR-R17779 is a nicotinic acetylcholine receptor alpha7 full agonist that targets α7 nAChR with high affinity (Ki = 92 nM/rat α7 against 5 nM α-BTX vs.16 μM/rat α4β2 against 3 nM (-)-nicotine) and selectivity (EC50 = 6.2/10/12.7 μM using human/rat/monkey α7 nAChR-Xenopus oocyte by whole cell voltage clamp, no antagonistic activity against acetylcholine using human α4β2-, α3β4-, α3β2-, α3β2α5-expressing oocytes or antagonistic activity against 5-HT using rat 5HT3a-exxpressing oocytes). AR-R17779 exhibits cognition-improving efficacy in rats (1-20 mg/kg s.c) and mice (1-20 mg/kg i.p.) in vivo and is widely employed for studying other α7 nAChR-dependent physiological functions.
Selective high affinity nicotinic acetylcholine receptor alpha7 (α7 nAChR) full agonist with in vivo cognition-improving efficacy.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

An efficient marker-free vector for clean gene transfer into plants
Xin C and Guo J
African Journal of Biotechnology, 11(16), 3751-3757 (2012)
A trans-zeatin riboside in root xylem sap negatively regulates adventitious root formation on cucumber hypocotyls
Kuroha T, et al.
Journal of Experimental Botany, 53(378), 2193-2200 (2002)
Structure of mistletoe lectin I from Viscum album in complex with the phytohormone zeatin
Meyer A, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1784(11), 1590-1595 (2008)
Systemic transport of trans-zeatin and its precursor have differing roles in Arabidopsis shoots
Osugi A, et al.
Nature plants, 3(8), 17112-17112 (2017)
Jianchang Yang et al.
Planta, 228(1), 137-149 (2008-03-15)
Early-flowered superior spikelets usually exhibit a faster grain filling rate and heavier grain weight than late-flowered inferior spikelets in rice (Oryza sativa L.). But the intrinsic factors responsible for the variations between the two types of spikelets are unclear. This

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service