Skip to Content
Merck
CN

Key Documents

View All Documentation

Skip To

SML2262

Sigma-Aldrich

Ramelteon

Synonym(s):

Ramelteon solution, (S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide, TAK 375, TAK-375

Sign Into View Organizational & Contract Pricing

Select a Size

10 MG
CN¥367.30
50 MG
CN¥4,957.43

CN¥367.30

List PriceCN¥1,224.32Save 70%

In StockDetails

New, lower price on this item!
Request a Bulk Order

Select a Size

Change View
10 MG
CN¥367.30
50 MG
CN¥4,957.43

About This Item

Empirical Formula (Hill Notation):
C16H21NO2
CAS Number:
196597-26-9
Molecular Weight:
259.34
MDL number:
MFCD08067736
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥367.30

List PriceCN¥1,224.32Save 70%

In StockDetails

New, lower price on this item!
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

powder

optical activity

[α]/D -50 to -60°, c = 1.0 in chloroform-d

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCC(NCC[C@H]1C(C(CCO2)=C2C=C3)=C3CC1)=O

InChI

1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1

InChI key

YLXDSYKOBKBWJQ-LBPRGKRZSA-N

Gene Information

human ... MTNR1A(4543), MTNR1B(4544)

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML1979SML1755SML2612
Ramelteon

SML2262

Ramelteon

FM-381 ≥98% (HPLC)

SML1979

FM-381

ML264 ≥98% (HPLC)

SML1755

ML264

KDS2010 ≥98% (HPLC)

SML2612

KDS2010

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 10 mL/mL, clear

solubility

H2O: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

optical activity

[α]/D -50 to -60°, c = 1.0 in chloroform-d

optical activity

-

optical activity

-

optical activity

-

Gene Information

human ... MTNR1A(4543), MTNR1B(4544)

Gene Information

-

Gene Information

-

Gene Information

-

Biochem/physiol Actions

Ramelteon is a cell penetrant, potent and selective agonist at MT1/MT2 melatonin receptor that exhibits sleep-promoting properties. It is not binding to GABA receptor complex. Ramelteon is an analog of melatonin recently approved to treat insomnia.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000282346
    0000282346
    0000194677
    0000194677
    0000134144

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Thomas Roth et al.
    Sleep, 28(3), 303-307 (2005-09-22)
    Evaluate the efficacy of ramelteon, an MT/1MT2-receptor agonist, for the treatment of transient insomnia in healthy adults. Randomized, double-blind, placebo-controlled design using a model of transient insomnia related to sleeping in a novel environment. Fourteen sleep research centers. Healthy adults
    Yasushi Yabuki et al.
    Molecular neurobiology, 55(4), 3577-3591 (2017-05-19)
    We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3
    Wei Zhou et al.
    PloS one, 11(11), e0166442-e0166442 (2016-11-11)
    "Perioceutics" including antimicrobial therapy and host modulatory therapy has emerged as a vital adjunctive treatment of periodontal disease. Melatonin level was significantly reduced in patients with periodontal diseases suggesting melatonin could be applied as a potential "perioceutics" treatment of periodontal
    Chuo Li et al.
    Bioengineered, 12(1), 4868-4877 (2021-08-05)
    Parkinson's disease (PD) is a common neurodegenerative disease with global health and economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction and oxidative stress are reported to participate in the pathological mechanism of PD. Ramelteon is a novel oral hypnotic agent that has

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service