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Merck
CN

SML2525

Tafluprost

≥98% (HPLC)

Synonym(s):

(5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168

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About This Item

Empirical Formula (Hill Notation):
C25H34F2O5
CAS Number:
209860-87-7
Molecular Weight:
452.53
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD08062150

Key Documents

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SMILES string

FC(F)(COc2ccccc2)\C=C\C1C(CC(C1C\C=C\CCCC(=O)OC(C)C)O)O

InChI

1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+

InChI key

WSNODXPBBALQOF-ZHDUIJGQSA-N

assay

≥98% (HPLC)

form

oil

optical activity

[α]/D +20 to +25°, c = 1 in chloroform-d

color

colorless to yellow

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

Prostaglandin F2α agonist; Antiglaucoma agent
Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361d

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000502187
0000502187
0000400031
0000400030
0000400030

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