SML2534
DJ-V-159
≥98% (HPLC)
Synonym(s):
N1,N3-Bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-1,3-Benzenedicarboxamide
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About This Item
Empirical Formula (Hill Notation):
C24H12F6N4O2
CAS Number:
Molecular Weight:
502.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
VEVNLJLJLVESLL-UHFFFAOYSA-N
SMILES string
O=C(C1=CC(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
DJ-V-159 is an agonist of GPRC6A, a family C G protein coupled receptor proposed to be master regulator of energy metabolism. GPRC6A is the receptor for osteocalcin, basic amino acids (e.g., L-Arginine), cations (e.g., calcium), and is a membrane receptor for testosterone. DJ-V-159 activated GPRC6A at 0.2 nM concentrations and stimulated GPRC6A-mediated ERK phosphorylation and cAMP accumulation in GPRC6A expressing HEK-293 cells. DJ-V-159 was found to stimulate insulin secretion from mouse β-cells and and lower serum glucose in wild-type mice.
GPRC6A agonist found to stimulate insulin secretion from mouse β-cells and and lower serum glucose in wild-type mice
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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