SML2605
TRPC6 PAM 51164
≥98% (HPLC)
Synonym(s):
N-(2-Chlorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide, N-(2-Chlorophenyl)-4-phenyl-1-piperazineacetamide
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About This Item
Empirical Formula (Hill Notation):
C18H20ClN3O
CAS Number:
Molecular Weight:
329.82
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C18H20ClN3O/c19-16-8-4-5-9-17(16)20-18(23)14-21-10-12-22(13-11-21)15-6-2-1-3-7-15/h1-9H,10-14H2,(H,20,23)
InChI key
PTAUSEMXADGRBI-UHFFFAOYSA-N
SMILES string
O=C(NC1=CC=CC=C1Cl)CN(CC2)CCN2C3=CC=CC=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
51164 is a neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates neuronal store-operated calcium entry (nSOCE) in the hippocampal neurons spines. 51164 fully rescues mushroom spines in Aβ42-treated neurons. It restores long-term potentiation (LTP) deficit in 6 months old hippocampal slices from 5xFAD mouse model.
neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates nSOCE in the hippocampal neurons spines
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Elena Popugaeva et al.
Molecular pharmacology, 95(4), 337-348 (2019-01-31)
Alzheimer's disease (AD) is a neurodegenerative disorder that is the major cause of dementia in the elderly. There is no cure against AD. We have recently discovered a novel transient receptor potential canonical 6 (TRPC6)-mediated intracellular signaling pathway that regulates
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