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SML2605

TRPC6 PAM 51164

≥98% (HPLC)

Synonym(s):

N-(2-Chlorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide, N-(2-Chlorophenyl)-4-phenyl-1-piperazineacetamide

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About This Item

Empirical Formula (Hill Notation):
C18H20ClN3O
CAS Number:
361473-63-4
Molecular Weight:
329.82
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=CC=CC=C1Cl)CN(CC2)CCN2C3=CC=CC=C3

InChI

1S/C18H20ClN3O/c19-16-8-4-5-9-17(16)20-18(23)14-21-10-12-22(13-11-21)15-6-2-1-3-7-15/h1-9H,10-14H2,(H,20,23)

InChI key

PTAUSEMXADGRBI-UHFFFAOYSA-N

Biochem/physiol Actions

51164 is a neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates neuronal store-operated calcium entry (nSOCE) in the hippocampal neurons spines. 51164 fully rescues mushroom spines in Aβ42-treated neurons. It restores long-term potentiation (LTP) deficit in 6 months old hippocampal slices from 5xFAD mouse model.
neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates nSOCE in the hippocampal neurons spines

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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