SML2751
UCSF7447
≥98% (HPLC)
Synonym(s):
2-Bromo-4-chloro-N-[3-(1H-1,2,4-triazol-5-yl)phenyl]-benzenemethanamine, ZINC555417447
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About This Item
Empirical Formula (Hill Notation):
C15H12BrClN4
CAS Number:
Molecular Weight:
363.64
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Brc1c(ccc(c1)Cl)CNc2cc(ccc2)c3[nH]ncn3
InChI
1S/C15H12BrClN4/c16-14-7-12(17)5-4-11(14)8-18-13-3-1-2-10(6-13)15-19-9-20-21-15/h1-7,9,18H,8H2,(H,19,20,21)
InChI key
QPTCYEYTAWEZNT-UHFFFAOYSA-N
Biochem/physiol Actions
UCSF7447 (ZINC555417447) brain permeable, potent and selective inverse agonist of both human and mouse melatonin MT1 receptor, which decelerates re-entrainment in mouse model of east-bound jetlag. Unexpectedly UCSF7447 advances the phase of the mouse circadian clock when administer at dusk.
brain permeable, potent and selective inverse agonist of both human and mouse melatonin MT1 receptor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Reed M Stein et al.
Nature, 579(7800), 609-614 (2020-02-11)
The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2751-5MG | 04061841874317 |
| SML2751-25MG | 04061841874300 |