SML2949
LY2112688 trifluoroacetate
≥95% (HPLC)
Synonym(s):
Ac-D-Arg-c(Cys-Glu-His-D-Phe-Arg-Trp-Cys)-NH2, trifluoroacetate salt, Ac-D-Arg-cyclo[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH2, trifluoroacetate salt, Ac-rCEHfRWC-NH2, TFA (D-amino acids in lower case; C2→C8 disulfide), Acetyl-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2, trifluoroacetate salt (Cys2→Cys8 disulfide), LY 2112688 TFA salt, LY-2112688 TFA salt
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About This Item
Empirical Formula (Hill Notation):
C51H70N18O11S2 · xC2HF3O2
CAS Number:
Molecular Weight:
1175.35 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥95% (HPLC)
Form:
lyophilized powder
Biochem/physiol Actions
High-affinity, potent and selective melanocortin receptor 4 (MC-4R, MC4-R, MC4R) agonist with in vivo efficacy in a chronic rat food intake and body weight model.
LY2112688 is a beta-melanocyte-stimulating hormone (β-MSH)-derived peptide that acts as a high-affinity, potent and selective melanocortin receptor 4 (MC-4, MC-4R, MC4-R, MC4R) agonist (human/rat MC-4 Ki = 0.55/0.39 nM; human MC-1/3/5 Ki = 16.78/56.79/>500 nM). LY2112688 selectively induces MC-4-mediated cAMP release (MC-4/3 EC50 = 0.25 nM/1.61 nM, MC-4/3 Emax = 94.5%/84.1% of NDP-α-MSH Emax using HEK293 expressing respective human receptors) and exhibits in vivo efficacy in reducing daily food intake and promoting weight loss among diet-induced obese rats (75 & 299 nmol/kg/day s.c.).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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