SML2996
SR-301
≥98% (HPLC)
Synonym(s):
6-(1H-Imidazol-1-yl)-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3-pyridazinecarboxamide, N-(2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-6-(1H-imidazol-1-yl)pyridazine-3-carboxamide, SR 301, SR301
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About This Item
Empirical Formula (Hill Notation):
C17H11F6N5O2
CAS Number:
Molecular Weight:
431.29
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(C1=NN=C(N2C=NC=C2)C=C1)NC3=C(C(O)(C(F)(F)F)C(F)(F)F)C=CC=C3
InChI key
COFASYKPDRGFKT-UHFFFAOYSA-N
Biochem/physiol Actions
Orally bioavailable analog of the selective STING agonist SR-717 with good antitumor efficacy in a murine B16.F10 melanoma tumor model in vivo.
SR-301 is an orally bioavailable analog of the selective STING agonist SR-717. SR-301 shows higher potency than SR-717 by THP1-based ISRE reporter assay (EC50 = 0.6 vs. 2.1 μM, respectively) and shows good antitumor efficacy when administered orally in a murine B16.F10 melanoma tumor model in vivo (15 mg/kg/day p.o.).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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