SML3070
PSEM89S Hydrochloride salt
≥98% (HPLC)
Synonym(s):
(S)-2,5-Dimethoxy-N-(quinuclidin-3-yl)benzamide, Hydrochloride salt, N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide Hydrochloride salt, PSEM 89S Hydrochloride salt, PSEM-89S Hydrochloride salt
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C16H22N2O3 · HCl
CAS Number:
Molecular Weight:
326.82
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N[C@@H]1CN2CCC1CC2)C3=C(C=CC(OC)=C3)OC.Cl
InChI
1S/C16H22N2O3.ClH/c1-20-12-3-4-15(21-2)13(9-12)16(19)17-14-10-18-7-5-11(14)6-8-18;/h3-4,9,11,14H,5-8,10H2,1-2H3,(H,17,19);1H/t14-;/m1./s1
InChI key
OHMFVSNTNXNVRE-PFEQFJNWSA-N
Biochem/physiol Actions
PSEM agonist for chimeric ligand-gated ion channel pores with nAChR α7 LBD L141F or L141F/Y115F mutant (PSAM) in vitro and in vivo.
PSEM89S is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML141F-GlyR & PSAML141F/Y115F-GlyR). 5-HT3 (PSAML141F-5-HT3 & PSAML141F/Y115F-5-HT3) and high-conductance 5-HT3 (PSAML141F-5-HT3 HC & PSAML141F/Y115F-5-HT3 HC).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Anna L Vlasits et al.
Neuron, 83(5), 1172-1184 (2014-08-27)
Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning
Serena Cerritelli et al.
PloS one, 11(4), e0153187-e0153187 (2016-04-15)
Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as cardiorespiratory depression. These drugs mimic peptides such as β-endorphin, which has a key role in endogenous analgesia. The
J Nicholas Betley et al.
Nature, 521(7551), 180-185 (2015-04-29)
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3070-5MG | 04065267027357 |
| SML3070-25MG | 04065267027340 |