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Merck
CN

SML3070

PSEM89S Hydrochloride salt

≥98% (HPLC)

Synonym(s):

(S)-2,5-Dimethoxy-N-(quinuclidin-3-yl)benzamide, Hydrochloride salt, N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide Hydrochloride salt, PSEM 89S Hydrochloride salt, PSEM-89S Hydrochloride salt

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About This Item

Empirical Formula (Hill Notation):
C16H22N2O3 · HCl
CAS Number:
1221570-55-3
Molecular Weight:
326.82
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

PSEM89S Hydrochloride salt, ≥98% (HPLC)

InChI

1S/C16H22N2O3.ClH/c1-20-12-3-4-15(21-2)13(9-12)16(19)17-14-10-18-7-5-11(14)6-8-18;/h3-4,9,11,14H,5-8,10H2,1-2H3,(H,17,19);1H/t14-;/m1./s1

InChI key

OHMFVSNTNXNVRE-PFEQFJNWSA-N

SMILES string

O=C(N[C@@H]1CN2CCC1CC2)C3=C(C=CC(OC)=C3)OC.Cl

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

PSEM agonist for chimeric ligand-gated ion channel pores with nAChR α7 LBD L141F or L141F/Y115F mutant (PSAM) in vitro and in vivo.
PSEM89S is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML141F-GlyR & PSAML141F/Y115F-GlyR). 5-HT3 (PSAML141F-5-HT3 & PSAML141F/Y115F-5-HT3) and high-conductance 5-HT3 (PSAML141F-5-HT3 HC & PSAML141F/Y115F-5-HT3 HC).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000137453
0000137452
0000137452
0000137453
0000133324

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Nature neuroscience, 19(2), 220-222 (2015-12-23)
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eLife, 6 (2017-10-14)
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