SML3262
TG11-77 Hydrochloride
≥98% (HPLC)
Synonym(s):
2-((4,6-dimethylpyridin-2-yl)amino)- N-(2-(2-methyl-lH-indol-3-yl)ethyl)pyrimidine-5-carboxamide Hydrochloride, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]- 5-pyrimidinecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C23H24N6O·HCl
CAS Number:
Molecular Weight:
436.94
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Brain-permeable, potent and selective EP2 receptor antagonist
TG11-77 is a brain-permeable, water soluble, highly potent, and selective EP2 receptor antagonist. TG11-77 suppress inflammatory gene expression induced by EP2 activation in a microglial cell line. TG11-77 is useful for study CNS diseases in rodent models.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease models.
Radhika Amaradhi, et al.
Journal of Medicinal Chemistry, 63(3), 1032-1050 (2020)
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