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SML3317

Losartan

≥98% (HPLC), powder, angiotensin II receptor type 1 (AT1) antagonist

Synonym(s):

1-[1-[[2′-(2H-Tetrazol-5-yl)biphenyl-4-yl]methyl]-2-butyl-4-chloro-1H-imidazol-5-yl]methanol, 2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1H-imidazole-5-methanol, 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, DUP 89

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About This Item

Empirical Formula (Hill Notation):
C22H23ClN6O
CAS Number:
114798-26-4
Molecular Weight:
422.91
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD19686114
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Product Name

Losartan, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2

InChI

1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

InChI key

PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Losartan is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan is used for treatment of hypertension.
Orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Lact. - Repr. 1B - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000548479
0000534666
0000528967
0000528967
0000548479

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P C Wong et al.
The Journal of pharmacology and experimental therapeutics, 255(2), 584-592 (1990-11-01)
DuP 753 and PD123177 are two nonpeptide angiotensin II (AII)-specific ligands, which show high affinities for two respective and distinct subtypes of AII binding sites, i.e., AII-1 and AII-2 sites, respectively, in the rat adrenal gland, brain and uterus. The
Yoon-A Park et al.
Journal of personalized medicine, 11(7) (2021-07-03)
This study aimed to investigate the influence of CYP2C9 genetic polymorphisms on the pharmacokinetics of losartan and its active metabolite, E-3174, through a systematic review and meta-analysis. Eight studies published before March 2021 were included in this study. We used
Daniel P Regan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 28(4), 662-676 (2021-09-29)
There is increasing recognition that progress in immuno-oncology could be accelerated by evaluating immune-based therapies in dogs with spontaneous cancers. Osteosarcoma (OS) is one tumor for which limited clinical benefit has been observed with the use of immune checkpoint inhibitors.

Global Trade Item Number

SKUGTIN
SML3317-50MG04065268048177
SML3317-10MG04065268048160

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