SML3325
Sob-AM2
≥98% (HPLC)
Synonym(s):
2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-N-methylacetamide
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About This Item
Empirical Formula (Hill Notation):
C21H27NO3
CAS Number:
Molecular Weight:
341.44
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC(C1=C(C=CC(CC2=C(C=C(C=C2C)OCC(NC)=O)C)=C1)O)C
InChI
1S/C21H27NO3/c1-13(2)18-10-16(6-7-20(18)23)11-19-14(3)8-17(9-15(19)4)25-12-21(24)22-5/h6-10,13,23H,11-12H2,1-5H3,(H,22,24)
InChI key
UWVFEENBJKSTRD-UHFFFAOYSA-N
General description
Sob-AM2 is a methyl amide derivative and a central nervous system (CNS)- selective prodrug of Sobetirome. Even in the absence of monocarboxylate transporter 8 (Mct8), Sob-AM2 can penetrate the brain and exhibit thyromimetic effects. It can promote extensive myelin repair in the brain and spinal cord of mouse models with demyelination. Sob-AM2 and other thyromimetics may also stimulate triggering receptor expressed on myeloid cell-2 (TREM2) expression in macrophages and microglia.
Biochem/physiol Actions
CNS-penetrating thyromimetic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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