SML3677
Cryosim-3
≥98% (HPLC)
Synonym(s):
1-Di(isopropyl)phosphinoyl-nonane, 1-Diisopropylphosphorylnonane, Bis(1-methylethyl)nonylphosphine oxide, DIPA 1-9
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About This Item
Empirical Formula (Hill Notation):
C15H33OP
CAS Number:
Molecular Weight:
260.40
UNSPSC Code:
12352200
NACRES:
NA.25
Quality Level
assay
≥98% (HPLC)
form
oil
color
colorless to yellow
storage temp.
2-8°C
SMILES string
O=P(C(C)C)(C(C)C)CCCCCCCCC
InChI key
DHOTYMJGZIUWRT-UHFFFAOYSA-N
Biochem/physiol Actions
Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease. Also it relieves ocular discomfort in subjects diagnosed with DED without eye irritation.
Water soluble, selective and potent agonist of TRPM8 receptor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ying Yin et al.
Science (New York, N.Y.), 378(6616), eadd1268-eadd1268 (2022-10-14)
The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2).
Jee Myung Yang et al.
BMC ophthalmology, 17(1), 101-101 (2017-06-28)
Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3677-5MG | 04065269112624 |
| SML3677-25MG | 04065269112617 |
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