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Merck
CN

SML4026

Sigma-Aldrich

ZH8651 hydrochloride

≥98% (HPLC)

Synonym(s):

2-(4-Bromophenyl)ethan-1-amine hydrochloride, 4-Bromobenzene-ethanamine hydrochloride, 4-Bromophenethylamine hydrochloride, p-Bromophenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H10BrN ·HCl
CAS Number:
Molecular Weight:
236.54
MDL number:
UNSPSC Code:
12352200
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Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC=C(C=C1)CCN.Cl

InChI

1S/C8H10BrN.ClH/c9-8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

ZHAWIPAHUYMLDV-UHFFFAOYSA-N

Biochem/physiol Actions

Orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1); dual activator of Gs and Gq in mTAAR1/hTAAR1.



ZH8651 is an orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8651 is dual activator of Gs and Gq in mTAAR1/hTAAR1 (EC50 = 9,85 nM (Gs), 66.5 nM Gq). ZH8651 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.

Pictograms

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Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Pan Shang et al.
Cell, 186(24), 5347-5362 (2023-11-15)
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy. Here, we systematically profiled the signaling properties of TAAR1 activation

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