SML4028
ZH8667 Hydrochloride
≥98% (HPLC)
Synonym(s):
3′-Fluoro[1,1′-biphenyl]-4-ethanamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H14FN· HCl
CAS Number:
Molecular Weight:
251.73
UNSPSC Code:
12352116
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NCCC1=CC=C(C2=CC(F)=CC=C2)C=C1.Cl
InChI key
UFFLABDFGANWCU-UHFFFAOYSA-N
Biochem/physiol Actions
orally available, potent and selective activator of Trace amine-associated receptor 1 (TAAR1); only activates Gs in mTAAR1/hTAAR1-overexpressing cells.
ZH8667 is an orally available, potent and selective activator of Trace amine-associated receptor 1 (TAAR1). ZH8667 only activates Gs in mTAAR1/hTAAR1-overexpressing cells (EC50 = 1.17 nM (Gs).
ZH8667 is an orally available, potent and selective activator of Trace amine-associated receptor 1 (TAAR1). ZH8667 only activates Gs in mTAAR1/hTAAR1-overexpressing cells (EC50 = 1.17 nM (Gs).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Pan Shang et al.
Cell, 186(24), 5347-5362 (2023-11-15)
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy. Here, we systematically profiled the signaling properties of TAAR1 activation
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML4028-25MG | 04065272050715 |
| SML4028-5MG | 04065272050722 |
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