SML4028
ZH8667 Hydrochloride
≥98% (HPLC)
Synonym(s):
3′-Fluoro[1,1′-biphenyl]-4-ethanamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H14FN· HCl
CAS Number:
Molecular Weight:
251.73
UNSPSC Code:
12352116
NACRES:
NA.21
InChI key
UFFLABDFGANWCU-UHFFFAOYSA-N
SMILES string
NCCC1=CC=C(C2=CC(F)=CC=C2)C=C1.Cl
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
orally available, potent and selective activator of Trace amine-associated receptor 1 (TAAR1); only activates Gs in mTAAR1/hTAAR1-overexpressing cells.
ZH8667 is an orally available, potent and selective activator of Trace amine-associated receptor 1 (TAAR1). ZH8667 only activates Gs in mTAAR1/hTAAR1-overexpressing cells (EC50 = 1.17 nM (Gs).
ZH8667 is an orally available, potent and selective activator of Trace amine-associated receptor 1 (TAAR1). ZH8667 only activates Gs in mTAAR1/hTAAR1-overexpressing cells (EC50 = 1.17 nM (Gs).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Pan Shang et al.
Cell, 186(24), 5347-5362 (2023-11-15)
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy. Here, we systematically profiled the signaling properties of TAAR1 activation
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