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Merck
CN

SRP6160

Sigma-Aldrich

FGF-4 human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

Synonym(s):

Fibroblast growth factor 4, HBGF4, Heparin-binding growth factor 4, K-fibroblast growth factor, KFGF

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

Key Documents

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biological source

human

recombinant

expressed in human cells

Assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

(17 and 27 kDa, monomer, glycosylated)

packaging

pkg of 10 μg

NCBI accession no.

P08620

UniProt accession no.

P08620

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FGF4(2249)

General description

The FGF4 (fibroblast growth factor 4) gene is mapped to human chromosome 11q13.3. It is expressed during early embryonic development. In adults, it is strongly expressed in the testis.

Biochem/physiol Actions

FGF4 (fibroblast growth factor 4) helps in preserving the self-renewal capability of normal stem cells. The encoded protein has the ability to interact with FGFR1c (FGF receptor 1c) and FGFR2c. It also binds to FGFR3c and FGFR4, but to a lesser extent. FGFR4 is also required for cellular differentiation, morphogenesis and proliferation. It modulates proliferation and differentiation of normal stem cells, progenitor cells and cancer cells.

Physical form

Lyophilized from a PBS solution.

Preparation Note

Centrifuge the vial prior to opening.
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
4K19L64490

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Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Yasuda K, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 94(12), 1355-1355 (2014)
Martina Johannesson et al.
PloS one, 4(3), e4794-e4794 (2009-03-12)
Retinoic acid (RA) and fibroblast growth factor 4 (FGF4) signaling control endoderm patterning and pancreas induction/expansion. Based on these findings, RA and FGFs, excluding FGF4, have frequently been used in differentiation protocols to direct differentiation of hESCs into endodermal and
Eryn Wicklow et al.
PLoS genetics, 10(10), e1004618-e1004618 (2014-10-24)
Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how pluripotency genes regulate cell fate decisions in the blastocyst provides a valuable
Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, et al.
Gene, 534(2), 435-439 (2014)
Evgeniya A Vaskova et al.
PloS one, 9(2), e88256-e88256 (2014-02-08)
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate
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