T2455
T3MG
Synonym(s):
(±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
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About This Item
Empirical Formula (Hill Notation):
C6H11NO4
CAS Number:
Molecular Weight:
161.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
form
powder
Quality Segment
color
white to off-white
solubility
H2O: >1.5 mg/dL
suitability
suitable for TLC (single spot)
storage temp.
room temp
SMILES string
C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
InChI
1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
InChI key
FHJNAFIJPFGZRI-WVZVXSGGSA-N
Biochem/physiol Actions
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4.
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.
Features and Benefits
This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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