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Merck
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T2576

Monoclonal Anti-TIS7 antibody produced in mouse

~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Interferon-Related Developmental Regulator 1 (IFRD1) (human), Anti-PC4 (rat), Anti-TPA-Induced Sequence 7 (mouse)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD08705605

Key Documents

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Product Name

Monoclonal Anti-TIS7 antibody produced in mouse, ~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

IRT537, monoclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

mouse, human

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7

isotype

IgG2a

UniProt accession no.

O00458

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)

Related Categories

Application

Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.

Biochem/physiol Actions

Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.

Immunogen

synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000174245
0000158482
0000174245
0000158482
095K4803

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Mutated genes and driver pathways involved in myelodysplastic syndromes?a transcriptome sequencing based approach.
Liu L
Molecular Biosystems, 11, 2158-2166 (2015)
IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23.
Brkanac Z
American Journal of Human Genetics, 84, 692-697 (2009)
PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB
Micheli L, et al.
Test, 286(7), 5691-5707 (2011)
The IFRD1 (57460C>T Polymorphism) Gene: A Negative Report in Cystic Fibrosis Clinical Severity
de Lima Marson
Journal of Molecular and Genetic Medicine, 7, 2-8 (2013)
Bart Tummers et al.
Nature communications, 6, 6537-6537 (2015-06-10)
High-risk human papillomaviruses (hrHPVs) infect keratinocytes and successfully evade host immunity despite the fact that keratinocytes are well equipped to respond to innate and adaptive immune signals. Using non-infected and freshly established or persistent hrHPV-infected keratinocytes we show that hrHPV
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