Key Documents

View All Documentation

T4951

2-((3-Trifluoromethyl)phenyl)histamine dimaleate

Name: 2-((3-Trifluoromethyl)phenyl)histamine dimaleate
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

(2-[2-(3-Trifluoromethyl)phenyl)-1H-imidazol-4-yl]ethanamine dimaleate, Compound 39

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₀F₃N₃O₈

CAS Number:

162049-83-4

Molecular Weight:

487.38

NACRES:

NA.77

PubChem Substance ID:

329826803

UNSPSC Code:

12352116

MDL number:

MFCD08277024

Assay:

≥98% (HPLC)

Form:

powder

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H₂O: ~20 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.NCCc1c[nH]c(n1)-c2cccc(c2)C(F)(F)F

InChI

1S/C12H12F3N3.2C4H4O4/c13-12(14,15)9-3-1-2-8(6-9)11-17-7-10(18-11)4-5-16;2*5-3(6)1-2-4(7)8/h1-3,6-7H,4-5,16H2,(H,17,18);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

InChI key

GGDUVPKRZGATLR-SPIKMXEPSA-N

Description

Application

2-((3-Trifluoromethyl)phenyl)histamine dimaleate has been used to study the induction of goblet cell secretion in rats³. 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has also been used to study the role of H1 receptor in COX-2 regulation and prostanoid homeostasis in human vascular endothelial cells⁴.

Biochem/physiol Actions

2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be the most potent and selective H₁ histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H₂, H₃, and other neurotransmitter receptors. It showed better potency at the guinea pig H₁ histamine receptor than at the human H₁ histamine receptor (pKi : 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H₁:H₂), > 64 (H₁:H₃), 1000 (H₁:M₃), 105 (H₁: a₁), 708 (H₁:β₁), and 71 (H₁:5HT_2A). 2-((3-Trifluoromethyl)phenyl)histamine dimaleate does not cross the blood-brain barrier.

Potent and selective H₁ histamine receptor agonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

2-((3-Trifluoromethyl)phenyl)histamine dimaleate is soluble in water at approximately 20 mg/ml.

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H301,H315,H318,H335

pcodes

P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c