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Merck
CN

T5651

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

Synonym(s):

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Empirical Formula (Hill Notation):
C11H17N3O8
CAS Number:
4368-28-9
Molecular Weight:
319.27
PubChem Substance ID:
24900308
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
49176
MDL number:
MFCD00213719

Key Documents

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SMILES string

OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

InChI key

CFMYXEVWODSLAX-IXUBDLNJSA-N

form

powder

availability

not available in USA

pH

4.8

solubility

H2O: soluble (stable at pH 4-5 if stored frozen), strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

storage temp.

2-8°C

Gene Information

rat ... Scnn1g(24768)

Application

Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.

Biochem/physiol Actions

Reversible, selective blocker of Na+ channels.
Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Packaging

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Preparation Note

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBB2938V
069K0684
038K1805
038K1804
018K0451

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Autism research : official journal of the International Society for Autism Research, 10(1), 42-65 (2016-08-06)
Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in
Hao Yang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(8), 1467-1482 (2019-06-04)
Irreversible neuron loss following spinal cord injury (SCI) usually results in persistent neurological dysfunction. The generation of autologous neural stem cells (NSCs) holds great potential for neural replenishment therapies and drug screening in SCI. Our recent studies demonstrated that mature
Miriam Michel et al.
Scientific reports, 9(1), 11888-11888 (2019-08-17)
Assessment of left ventricular mass (LVM) is important in the evaluation of patients with congenital heart disease (CHD) and cardiac magnetic resonance imaging (CMR) is the gold standard. Recent software allows LVM calculation by real-time 3-dimensional echocardiography (RT3DE). We investigated
Jannis E Meents et al.
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The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients
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