Skip to Content
Merck
CN

T9265

Thyrotropic hormone from human pituitary

lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)

Synonym(s):

hTSH, TSH, Thyroid stimulating hormone

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

CAS Number:
9002-71-5
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD00132432

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Thyrotropic hormone from human pituitary, lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)

biological source

human pituitary glands

sterility

non-sterile

form

lyophilized powder

specific activity

≥6.2 IU/mg (immunoassay, non-sterile)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

cell culture | mammalian: suitable

impurities

HIV Antibodies
Antibody to HCV
Antibody to HBV or Presence of HBSAG, tested negative

UniProt accession no.

P01222
P16473

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... TSHB(7252), TSHR(7253)

Looking for similar products? Visit Product Comparison Guide

Application

Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation. It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.

Biochem/physiol Actions

In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment. Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins. In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

General description

Research area: Cell Signaling

Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.

Packaging

Package size based on hormone

Physical form

Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKDB0459
MKCZ4503
MKCZ4504
MKCZ4498
MKCZ4497

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Impact of light exposure on thyroid-stimulating hormone results using the Siemens Advia Centaur TSH-3Ultra assay
Armer J, et al.
Annals of Clinical Biochemistry, 54(5), 612-615 (2017)
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships
Szkudlinski MW, et al.
Physiological Reviews, 82(2), 473-502 (2002)
Zhenghao Wu et al.
Journal for immunotherapy of cancer, 10(1) (2022-02-02)
Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response were far from clear. The source
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service