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U104

UK 14,304

Synonym(s):

5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

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About This Item

Empirical Formula (Hill Notation):
C11H10BrN5
CAS Number:
59803-98-4
Molecular Weight:
292.13
NACRES:
NA.77
PubChem Substance ID:
24277812
UNSPSC Code:
12352200
MDL number:
MFCD00153878
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Quality Segment

100

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL, DMSO: >6.5 mg/mL, ethanol: <8 mg/mL (warm), H2O: insoluble

SMILES string

Brc1c(NC2=NCCN2)ccc3nccnc13

InChI

1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChI key

XYLJNLCSTIOKRM-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Application

UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture
UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.

Biochem/physiol Actions

UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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