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U6750

Uridine 5′-triphosphate trisodium salt hydrate

Name: Uridine 5&#8242;-triphosphate trisodium salt hydrate
Brand: SIGMA

≥93.0% (HPLC), Thyroid hormone

Synonym(s):

UTP Na₃

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂Na₃O₁₅P₃ · xH₂O

CAS Number:

19817-92-6

Molecular Weight:

550.09 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24900658

UNSPSC Code:

12352200

EC Number:

243-347-5

MDL number:

MFCD00044310

Beilstein/REAXYS Number:

3585234

Assay:

≥93.0% (HPLC)

Quality level:

200

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Product Name

Uridine 5′-triphosphate trisodium salt hydrate, Type IV, ≥93.0% (HPLC)

type

Type IV

Quality Level

200

assay

≥93.0% (HPLC)

solubility

H₂O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

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Related Categories

Bioactive Small Molecules

Phosphates

Bioactive Small Molecule Agonists

Application

Uridine 5′-triphosphate has been used in a study to show that fluoxetine (FLX), mediates its anti-depressive effect by increasing the gliotransmission of adenosine 5′-triphosphate (ATP).

UTP has been used as a P2 receptor activator to study its effects on proton efflux in MC3T3-E1 and UMR-106 cells. UTP has also been studied in combination with amiloride hydrochloride in nebulizer solutions for treating cystic fibrosis.

Biochem/physiol Actions

Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.

P2Y receptor agonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

25 mg of Uridine 5′-triphosphate trisodium salt (UTP Na₃) hydrate is soluble in 0.5 ml of water and yields a clear, colorless solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Uridine-5?-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells

Palomo-Guerrero M, et al.

Neuroscience, 372(2), 255-265 (2018)

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

Kinoshita M, et al.

EBioMedicine, 372(2), 255-265 (2018)

Ionic interaction of amiloride and uridine 5'-triphosphate in nebulizer solutions.

Ronald J Pettis et al.

Journal of pharmaceutical sciences, 93(9), 2399-2406 (2004-08-06)

Combination therapy using nebulized amiloride hydrochloride and uridine-5'-triphosphate (UTP) trisodium salt aerosols has been investigated for the treatment of cystic fibrosis (CF). Amiloride in aqueous solution precipitates in the presence of UTP, reducing drug concentrations. Interactions between these drugs and

Intralesional uridine-5?-triphosphate (UTP) treatment induced resistance to Leishmania amazonensis infection by boosting Th 1 immune responses and reactive oxygen species production

Marques-da-Silva C, et al.

Purinergic Signaling, 14(2), 201-211 (2018)

Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex.

Jiqin Wu et al.

Cell reports, 37(4), 109882-109882 (2021-10-16)

Remdesivir (RDV), a nucleotide analog with broad-spectrum features, has exhibited effectiveness in COVID-19 treatment. However, the precise working mechanism of RDV when targeting the viral RNA-dependent RNA polymerase (RdRP) has not been fully elucidated. Here, we solve a 3.0-Å structure

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Global Trade Item Number

SKU	GTIN
U6750-250MG	04061832086378
U6750-1G	04061825983851
U6750-100MG	04061832086361
U6750-500MG	04061837409936

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