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U6750

Uridine 5′-triphosphate trisodium salt hydrate

≥93.0% (HPLC), Thyroid hormone

Synonym(s):

UTP Na3

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About This Item

Empirical Formula (Hill Notation):
C9H12N2Na3O15P3 · xH2O
CAS Number:
19817-92-6
Molecular Weight:
550.09 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24900658
UNSPSC Code:
12352200
EC Number:
243-347-5
MDL number:
MFCD00044310
Beilstein/REAXYS Number:
3585234
Assay:
≥93.0% (HPLC)
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Product Name

Uridine 5′-triphosphate trisodium salt hydrate, Type IV, ≥93.0% (HPLC)

type

Type IV

Quality Segment

200

assay

≥93.0% (HPLC)

solubility

H2O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

Application

Uridine 5′-triphosphate has been used in a study to show that fluoxetine (FLX), mediates its anti-depressive effect by increasing the gliotransmission of adenosine 5′-triphosphate (ATP).
UTP has been used as a P2 receptor activator to study its effects on proton efflux in MC3T3-E1 and UMR-106 cells. UTP has also been studied in combination with amiloride hydrochloride in nebulizer solutions for treating cystic fibrosis.

Biochem/physiol Actions

Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.
P2Y receptor agonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

25 mg of Uridine 5′-triphosphate trisodium salt (UTP Na3) hydrate is soluble in 0.5 ml of water and yields a clear, colorless solution.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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