U7508
Anti-UVRAG antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-UV radiation resistance-associated gene
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~90 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
western blot: 2-4 μg/mL using whole extracts of mouse brain and human Hela cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... UVRAG(7405)
mouse ... Uvrag(78610)
General description
UVRAG activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a prot
Ultraviolet irradiation resistance-associated gene (UVRAG) is an important autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.
Immunogen
synthetic peptide corresponding to amino acids 665-678 of human UVRAG, conjugated to KLH. The corresponding sequence is identical in mouse.
Application
Anti-UVRAG antibody has been used in:
- immunoblotting
- western blotting
- immunofluorescence
Anti-UVRAG antibody produced in rabbit has been used:
- in western blotting
- in immunofluorescence
Biochem/physiol Actions
Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication
Gladue D P, et al.
Journal of Virology, 86(22), 12080-12090 (2012)
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Curtis C
Nature, 486, 346-352 (2012)
Chonsaeng Kim et al.
Journal of virology, 88(1), 434-443 (2013-10-25)
Echovirus 7 enters polarized Caco-2 intestinal epithelial cells by a clathrin-mediated endocytic process and then moves through the endosomal system before releasing its genome into the cytoplasm. We examined the possible role in virus entry of core components of the
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.
Yin X
EMBO Reports, 12, 727-734 (2011)
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Knaevelsrud H, et al.
Autophagy, 6(7), 863-870 (2010)
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