V2514
Anti-VGLUT2 (HY-19) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-DNPI, Anti-VGLUT2
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 65 kDa
species reactivity
rat
technique(s)
western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC17A6(57084)
mouse ... Slc17a6(140919)
rat ... Slc17a6(84487)
General description
Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.
Immunogen
synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.
Application
Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:
- western blot
- immunolabelling.
- immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
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Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia.
Moyer C E, et al.
Schizophrenia Research, 149(1), 127-134 (2013)
Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres.
Virolainen S-M, et al.
Development, 139(20), 3795-3805 (2012)
SLC17: a functionally diverse family of organic anion transporters.
Reimer R J.
Molecular Aspects of Medicine, 350-359, 34(2-343) (2013)
Expression of vesicular glutamate transporter 2 (vGluT2) on large dense-core vesicles within GnRH neuroterminals of aging female rats.
Yin W, et al.
PLoS ONE, 10(6), e0129633-e0129633 (2015)
Growth and refinement of excitatory synapses in the human auditory cortex.
.Pundir A S, et al.
Brain Structure &Amp; Function, 221(7), 3641-3674 (2016)
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